Developing inhibitors of bromodomain-histone interactions

Developing inhibitors of bromodomain-histone interactions

<p>Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s. However, it has only become apparent sinc...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखक:	Hewings, D
अन्य लेखक:	Conway, S
स्वरूप:	थीसिस
भाषा:	English
प्रकाशित:	2014
विषय:	Chemical biology Physical Sciences Organic chemistry Organic synthesis Chemistry & allied sciences

समान संसाधन

Development of small molecule inhibitors of the bromodomain-histone interaction
द्वारा: Rooney, TPC
प्रकाशित: (2014)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
द्वारा: Hay, D
प्रकाशित: (2014)

Palladium mediated allylic fluorination
द्वारा: Hollingworth, C
प्रकाशित: (2013)

Aziridinations of tethered allenes
द्वारा: Feast, GC
प्रकाशित: (2011)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
द्वारा: Poingdestre, SJ
प्रकाशित: (2012)

Development of ligands to target bromodomain-histone interactions
द्वारा: Jennings, L
प्रकाशित: (2015)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
द्वारा: Hewings, D, और अन्य
प्रकाशित: (2011)

Novel di-branched monosaccharides and imino sugars
द्वारा: Barker, K, और अन्य
प्रकाशित: (2009)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
द्वारा: Carter, JL
प्रकाशित: (2023)

Olefin metathesis for site-selective protein modification
द्वारा: Lin, YA
प्रकाशित: (2013)

Phosphoramidite ligand design for the enantioselective conjugate addition of alkylzirconium reagents to enones
द्वारा: Roth, PMC
प्रकाशित: (2014)

Alkaloids from transannular iodoaminations
द्वारा: Brock, E
प्रकाशित: (2012)

Palladium-catalysed cyclisations of bromoenynamides in the synthesis and applications of amidodienes
द्वारा: Greenaway, R
प्रकाशित: (2013)

Determining the structures of halogenated marine natural products by total synthesis
द्वारा: Dyson, BS
प्रकाशित: (2011)

Cation-controlled diastereo- and enantioselective synthesis of indolines: an autocatalytic process
द्वारा: Sharma, K
प्रकाशित: (2014)

Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
द्वारा: Michaelides, IN
प्रकाशित: (2014)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
द्वारा: Kaka, N, और अन्य
प्रकाशित: (2008)

Palladium- and copper-catalysed heterocycle synthesis
द्वारा: Ball, C
प्रकाशित: (2014)

Synthesis and elaboration of heterocycles via palladium-catalyzed C-H functionalization
द्वारा: Gerelle, M
प्रकाशित: (2012)

Studies towards the stereoselective synthesis of alkenes
द्वारा: Arif, T
प्रकाशित: (2011)

Chiral cation-directed asymmetric 5-endo-trig cyclizations
द्वारा: Johnston, CP
प्रकाशित: (2013)

Design and synthesis of inositol phosphate-based probes
द्वारा: Slowey, A
प्रकाशित: (2013)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
द्वारा: Hodgson, D, और अन्य
प्रकाशित: (2008)

Asymmetric syntheses of β- and γ-amino acids
द्वारा: Zammit, C
प्रकाशित: (2015)

Reactions of allenylpalladium intermediates in organic synthesis
द्वारा: Daniels, DSB
प्रकाशित: (2013)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
द्वारा: Donohoe, T, और अन्य
प्रकाशित: (2011)

Transition metal catalysed C-C bond formation via C-H functionalisation
द्वारा: Truscott, FR
प्रकाशित: (2012)

The synthesis and biology of iminosugars and their precursors
द्वारा: Ayers, B, और अन्य
प्रकाशित: (2014)

Studies towards the total synthesis of manzamine A
द्वारा: Hawkins, A
प्रकाशित: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
द्वारा: Cordonnier, M, और अन्य
प्रकाशित: (2011)

Enantiorecognition phenomena in asymmetric synthesis
द्वारा: Yin, J, और अन्य
प्रकाशित: (2011)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
द्वारा: Pattarakiat, Seankongsuk
प्रकाशित: (2022)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
द्वारा: Rydzik, AM
प्रकाशित: (2014)

Asymmetric synthesis of piperidine alkaloids
द्वारा: Thomson, A, और अन्य
प्रकाशित: (2012)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
द्वारा: Lenden, P
प्रकाशित: (2011)

Synthesis of mono- and bicyclic azacycles via palladium- and ruthenium-catalysed enynamide cycloisomerisation
द्वारा: Walker, P, और अन्य
प्रकाशित: (2014)

Halogen bonding interlocked host systems for recognition and sensing of anions
द्वारा: Mullaney, B, और अन्य
प्रकाशित: (2014)

A glycopore for bacterial sensing
द्वारा: Shanley, SJ
प्रकाशित: (2009)

Novel palladium-catalysed routes to aromatic heterocycles
द्वारा: Pilgrim, B, और अन्य
प्रकाशित: (2013)

An ion-binding approach to asymmetric allylation reactions
द्वारा: Stovold, CP
प्रकाशित: (2013)