Oncometabolite induced primary cilia loss in pheochromocytoma

Primary cilia are sensory organelles involved in regulation of cellular signaling. Cilia loss is frequently observed in tumors; yet, the responsible mechanisms and consequences for tumorigenesis remain unclear. We demonstrate that cilia structure and function is disrupted in human pheochromocytomas...

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Bibliographic Details
Main Authors: O'Toole, SM, Watson, DS, Novoselova, TV, Romano, LEL, King, PJ, Bradshaw, TY, Thompson, CL, Knight, MM, Sharp, TV, Barnes, MR, Srirangalingam, U, Drake, WM, Chapple, JP
Format: Journal article
Language:English
Published: Bioscientifica 2019