Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

The Hedgehog (Hh) pathway plays a central role in the development of multicellular organisms, guiding cell differentiation, proliferation and survival. While many components of the vertebrate pathway were discovered two decades ago, the mechanism by which the Hh signal is transmitted across the plas...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Byrne, E, Luchetti, G, Rohatgi, R, Siebold, C
Fformat:	Journal article
Cyhoeddwyd:	Elsevier 2017

Eitemau Tebyg

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
gan: Nachtergaele, S, et al.
Cyhoeddwyd: (2013)

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling
gan: Rohatgi, Rajat, et al.
Cyhoeddwyd: (2014)

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
gan: Kowatsch, C, et al.
Cyhoeddwyd: (2019)

Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class F G protein-coupled receptor smoothened
gan: Hedger, G, et al.
Cyhoeddwyd: (2018)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
gan: Jie Zhang, et al.
Cyhoeddwyd: (2021-08-01)

Biochemical mechanisms of vertebrate hedgehog signaling
gan: Kong, J, et al.
Cyhoeddwyd: (2019)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
gan: Zhao, Zhonghua, et al.
Cyhoeddwyd: (2016)

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling
gan: Luchetti, G, et al.
Cyhoeddwyd: (2016)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
gan: Byrne, E
Cyhoeddwyd: (2017)

Structural basis for Smoothened regulation by its extracellular domains
gan: Siebold, C, et al.
Cyhoeddwyd: (2016)

Patched-1 and smoothened, a hedgehog receptor and signal transducer are highly expressed in diffuse large B-cell lymphoma
gan: Azman, Siti Nur Lina, et al.
Cyhoeddwyd: (2017)

A recurrent mosaic mutation of SMO, encoding the hedgehog signal transducer Smoothened, is the major cause of Curry-Jones syndrome
gan: Twigg, S, et al.
Cyhoeddwyd: (2016)

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis
gan: Woolley, R
Cyhoeddwyd: (2021)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
gan: Klindert, S
Cyhoeddwyd: (2023)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
gan: Shuang Li, et al.
Cyhoeddwyd: (2012-01-01)

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
gan: Madison F Walker, et al.
Cyhoeddwyd: (2024-08-01)

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.
gan: Shoujun Huang, et al.
Cyhoeddwyd: (2013-11-01)

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development
gan: Ketley, A, et al.
Cyhoeddwyd: (2013)

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development.
gan: Ami Ketley, et al.
Cyhoeddwyd: (2013-01-01)

Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling
gan: Kinnebrew, M, et al.
Cyhoeddwyd: (2019)

Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions
gan: Suifang Mao, et al.
Cyhoeddwyd: (2025-03-01)

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.
gan: Bishop, B, et al.
Cyhoeddwyd: (2009)

Cilia-associated oxysterols activate Smoothened
gan: Raleigh, DR, et al.
Cyhoeddwyd: (2018)

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
gan: Wang J, et al.
Cyhoeddwyd: (2024-11-01)

Structural insights into proteoglycan-shaped Hedgehog signaling.
gan: Whalen, D, et al.
Cyhoeddwyd: (2013)

Interactions between Hedgehog proteins and their binding partners come into view.
gan: Beachy, P, et al.
Cyhoeddwyd: (2010)

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
gan: Nihal AlMuraikhi, et al.
Cyhoeddwyd: (2019-01-01)

Cortisol regulates neonatal lung development via Smoothened
gan: Shanshan Lu, et al.
Cyhoeddwyd: (2025-01-01)

Photochemical probe identification of a small-molecule inhibitor binding site in Hedgehog acyltransferase (HHAT)
gan: Lanyon-Hogg, T, et al.
Cyhoeddwyd: (2021)

Cyclopamine modulates smoothened receptor activity in a binding position dependent manner
gan: Kihong Kim, et al.
Cyhoeddwyd: (2024-09-01)

Linear and nonlinear approach for DEM smoothening
gan: S. Dinesh, et al.
Cyhoeddwyd: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
Cyhoeddwyd: (2006-01-01)

Hedgehog signalling
gan: Lee, Raymond Teck Ho, et al.
Cyhoeddwyd: (2016)

Hedgehog signaling regulates gene expression in planarian glia
gan: Scimone, M Lucila, et al.
Cyhoeddwyd: (2016)

Numb positively regulates Hedgehog signaling at the ciliary pocket
gan: Xiaoliang Liu, et al.
Cyhoeddwyd: (2024-04-01)

A Smoothening Method for the Piecewise Linear Interpolation
gan: Beong In Yun
Cyhoeddwyd: (2015-01-01)

Structural and functional characterisation of hedgehog ligand-receptor complexes
gan: Bishop, BF
Cyhoeddwyd: (2013)

Investigating the role of lipids and small-molecule ligands in hedgehog signalling using molecular dynamics simulations
gan: Ansell, T
Cyhoeddwyd: (2022)

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex
gan: Beth Mann, et al.
Cyhoeddwyd: (2023-06-01)

Paralog-specific TTC30 regulation of Sonic hedgehog signaling
gan: Felix Hoffmann, et al.
Cyhoeddwyd: (2023-11-01)