Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

The Hedgehog (Hh) pathway plays a central role in the development of multicellular organisms, guiding cell differentiation, proliferation and survival. While many components of the vertebrate pathway were discovered two decades ago, the mechanism by which the Hh signal is transmitted across the plas...

Bibliografski detalji
Glavni autori:	Byrne, E, Luchetti, G, Rohatgi, R, Siebold, C
Format:	Journal article
Izdano:	Elsevier 2017

Slični predmeti

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
od: Nachtergaele, S, i dr.
Izdano: (2013)

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling
od: Rohatgi, Rajat, i dr.
Izdano: (2014)

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
od: Kowatsch, C, i dr.
Izdano: (2019)

Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class F G protein-coupled receptor smoothened
od: Hedger, G, i dr.
Izdano: (2018)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
od: Jie Zhang, i dr.
Izdano: (2021-08-01)

Biochemical mechanisms of vertebrate hedgehog signaling
od: Kong, J, i dr.
Izdano: (2019)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
od: Zhao, Zhonghua, i dr.
Izdano: (2016)

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling
od: Luchetti, G, i dr.
Izdano: (2016)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
od: Byrne, E
Izdano: (2017)

Structural basis for Smoothened regulation by its extracellular domains
od: Siebold, C, i dr.
Izdano: (2016)

Patched-1 and smoothened, a hedgehog receptor and signal transducer are highly expressed in diffuse large B-cell lymphoma
od: Azman, Siti Nur Lina, i dr.
Izdano: (2017)

A recurrent mosaic mutation of SMO, encoding the hedgehog signal transducer Smoothened, is the major cause of Curry-Jones syndrome
od: Twigg, S, i dr.
Izdano: (2016)

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis
od: Woolley, R
Izdano: (2021)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
od: Klindert, S
Izdano: (2023)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
od: Shuang Li, i dr.
Izdano: (2012-01-01)

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
od: Madison F Walker, i dr.
Izdano: (2024-08-01)

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.
od: Shoujun Huang, i dr.
Izdano: (2013-11-01)

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development
od: Ketley, A, i dr.
Izdano: (2013)

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development.
od: Ami Ketley, i dr.
Izdano: (2013-01-01)

Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling
od: Kinnebrew, M, i dr.
Izdano: (2019)

Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions
od: Suifang Mao, i dr.
Izdano: (2025-03-01)

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.
od: Bishop, B, i dr.
Izdano: (2009)

Cilia-associated oxysterols activate Smoothened
od: Raleigh, DR, i dr.
Izdano: (2018)

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
od: Wang J, i dr.
Izdano: (2024-11-01)

Structural insights into proteoglycan-shaped Hedgehog signaling.
od: Whalen, D, i dr.
Izdano: (2013)

Interactions between Hedgehog proteins and their binding partners come into view.
od: Beachy, P, i dr.
Izdano: (2010)

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
od: Nihal AlMuraikhi, i dr.
Izdano: (2019-01-01)

Cortisol regulates neonatal lung development via Smoothened
od: Shanshan Lu, i dr.
Izdano: (2025-01-01)

Photochemical probe identification of a small-molecule inhibitor binding site in Hedgehog acyltransferase (HHAT)
od: Lanyon-Hogg, T, i dr.
Izdano: (2021)

Cyclopamine modulates smoothened receptor activity in a binding position dependent manner
od: Kihong Kim, i dr.
Izdano: (2024-09-01)

Linear and nonlinear approach for DEM smoothening
od: S. Dinesh, i dr.
Izdano: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
Izdano: (2006-01-01)

Hedgehog signalling
od: Lee, Raymond Teck Ho, i dr.
Izdano: (2016)

Hedgehog signaling regulates gene expression in planarian glia
od: Scimone, M Lucila, i dr.
Izdano: (2016)

Numb positively regulates Hedgehog signaling at the ciliary pocket
od: Xiaoliang Liu, i dr.
Izdano: (2024-04-01)

A Smoothening Method for the Piecewise Linear Interpolation
od: Beong In Yun
Izdano: (2015-01-01)

Structural and functional characterisation of hedgehog ligand-receptor complexes
od: Bishop, BF
Izdano: (2013)

Investigating the role of lipids and small-molecule ligands in hedgehog signalling using molecular dynamics simulations
od: Ansell, T
Izdano: (2022)

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex
od: Beth Mann, i dr.
Izdano: (2023-06-01)

Paralog-specific TTC30 regulation of Sonic hedgehog signaling
od: Felix Hoffmann, i dr.
Izdano: (2023-11-01)