Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.

A worker in a polyvinyl chloride factory with rapidly progressive diffuse cutaneous scleroderma was treated with the humanized monoclonal antibody (Mab) CAMPATH-1H. Treatment was followed by rapid and substantial improvement in skin score, which was maintained during followup without additional ther...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Isaacs, J, Hazleman, B, Chakravarty, K, Grant, J, Hale, G, Waldmann, H
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1996
Miêu tả
Tóm tắt:A worker in a polyvinyl chloride factory with rapidly progressive diffuse cutaneous scleroderma was treated with the humanized monoclonal antibody (Mab) CAMPATH-1H. Treatment was followed by rapid and substantial improvement in skin score, which was maintained during followup without additional therapy. The mode of action of CAMPATH-1H and its relationship to clinical improvement are discussed.