Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

<p>High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzyme...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Williams, J
Awduron Eraill:	Harris, A
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2013
Pynciau:	Organic synthesis Enzymes Tumours Synthetic organic chemistry Metabolism Oncology

Eitemau Tebyg

Isoenzyme-specific PFK-2/FBPase-2 Inhibition as an Anti-cancer Strategy
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The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors
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Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases
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New methods for nucleophilic fluorination
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Stereoselective cyclopropanations of allylic amines and derivatives
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The synthesis of azetidine and piperidine iminosugars from monosaccharides
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Selective routes to substituted dihydropyridones
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Synthesis of taurospongin A and other biologically active natural products
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Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides: studies towards the syntheses of inthomycin B and inthomycin C
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Rare monosaccharides and biologically active iminosugars from carbohydrate chirons
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Methodology for the synthesis of NP25302 and other bioactive natural products
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Hydrogen-bonding motifs for non-covalent synthesis
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Oxidative radical cyclisations for total synthesis
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Synthesis of the pyrrolidinone core of oxazolomycin A
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Asymmetric synthesis of amino polyols
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The use of functionalised lithium amides in the total synthesis of alkaloids
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Synthesis studies towards daphlongeranine B
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Enantioselective synthesis and reactivity of benzylic fluorides
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Alkaloids from transannular iodoaminations
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Palladium-catalysed enolate arylation in the synthesis of isoquinolines
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Lithiated azetidine and azetine chemistry
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Total syntheses of the nakinadine alkaloids
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Cyclisation cascades via reactive iminium intermediates
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Rhodium catalysed hydroacylation reactions in the synthesis of heterocycles
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Studies towards the stereoselective synthesis of alkenes
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Studies towards the total synthesis of manzamine A
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The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles
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Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
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The synthesis and biology of iminosugars and their precursors
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The synthesis and applications of cyclic alkenylsiloxanes
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Transition metal catalysed C-C bond formation via C-H functionalisation
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Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
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Synthesis of complex γ-lactones mediated by manganese(III)
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Synthesis of the ABC fragment of pectenotoxin-4
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Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
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Aziridinations of tethered allenes
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Asymmetric synthesis of piperidine alkaloids
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Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
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Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
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