Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

<p>High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzyme...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखक:	Williams, J
अन्य लेखक:	Harris, A
स्वरूप:	थीसिस
भाषा:	English
प्रकाशित:	2013
विषय:	Organic synthesis Enzymes Tumours Synthetic organic chemistry Metabolism Oncology

समान संसाधन

Isoenzyme-specific PFK-2/FBPase-2 Inhibition as an Anti-cancer Strategy
द्वारा: Williams, J, और अन्य
प्रकाशित: (2012)

Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting
द्वारा: Glawar, AFG
प्रकाशित: (2013)

The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors
द्वारा: Crabtree, E, और अन्य
प्रकाशित: (2011)

Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases
द्वारा: Thalhammer, A
प्रकाशित: (2012)

New methods for nucleophilic fluorination
द्वारा: Cresswell, A
प्रकाशित: (2011)

Stereoselective cyclopropanations of allylic amines and derivatives
द्वारा: Ling, K, और अन्य
प्रकाशित: (2009)

The synthesis of azetidine and piperidine iminosugars from monosaccharides
द्वारा: Lenagh-Snow, G, और अन्य
प्रकाशित: (2012)

Selective routes to substituted dihydropyridones
द्वारा: Connolly, M, और अन्य
प्रकाशित: (2011)

Synthesis of taurospongin A and other biologically active natural products
द्वारा: Wu, B
प्रकाशित: (2017)

Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides: studies towards the syntheses of inthomycin B and inthomycin C
द्वारा: Baker, D
प्रकाशित: (2014)

Rare monosaccharides and biologically active iminosugars from carbohydrate chirons
द्वारा: Best, D
प्रकाशित: (2011)

Methodology for the synthesis of NP25302 and other bioactive natural products
द्वारा: Stevens, K
प्रकाशित: (2011)

Hydrogen-bonding motifs for non-covalent synthesis
द्वारा: Pearson, JM
प्रकाशित: (2013)

Oxidative radical cyclisations for total synthesis
द्वारा: Ferrara, S
प्रकाशित: (2013)

Synthesis of the pyrrolidinone core of oxazolomycin A
द्वारा: O'Riordan, TJC
प्रकाशित: (2009)

Asymmetric synthesis of amino polyols
द्वारा: Foster, E
प्रकाशित: (2012)

The use of functionalised lithium amides in the total synthesis of alkaloids
द्वारा: Lee, JA
प्रकाशित: (2012)

Synthesis studies towards daphlongeranine B
द्वारा: Kallstrom, JED
प्रकाशित: (2013)

Enantioselective synthesis and reactivity of benzylic fluorides
द्वारा: Blessley, G, और अन्य
प्रकाशित: (2013)

Alkaloids from transannular iodoaminations
द्वारा: Brock, E
प्रकाशित: (2012)

Palladium-catalysed enolate arylation in the synthesis of isoquinolines
द्वारा: Gatland, A, और अन्य
प्रकाशित: (2014)

Lithiated azetidine and azetine chemistry
द्वारा: Pearson, CI
प्रकाशित: (2014)

Total syntheses of the nakinadine alkaloids
द्वारा: Shah, R
प्रकाशित: (2013)

Cyclisation cascades via reactive iminium intermediates
द्वारा: Gregory, AW
प्रकाशित: (2014)

Rhodium catalysed hydroacylation reactions in the synthesis of heterocycles
द्वारा: Ylioja, P
प्रकाशित: (2011)

Studies towards the stereoselective synthesis of alkenes
द्वारा: Arif, T
प्रकाशित: (2011)

Studies towards the total synthesis of manzamine A
द्वारा: Hawkins, A
प्रकाशित: (2013)

The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles
द्वारा: Barber, D, और अन्य
प्रकाशित: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
द्वारा: Cordonnier, M, और अन्य
प्रकाशित: (2011)

The synthesis and biology of iminosugars and their precursors
द्वारा: Ayers, B, और अन्य
प्रकाशित: (2014)

The synthesis and applications of cyclic alkenylsiloxanes
द्वारा: Elbert, B, और अन्य
प्रकाशित: (2014)

Transition metal catalysed C-C bond formation via C-H functionalisation
द्वारा: Truscott, FR
प्रकाशित: (2012)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
द्वारा: Saliba, R, और अन्य
प्रकाशित: (2014)

Synthesis of complex γ-lactones mediated by manganese(III)
द्वारा: Logan, A
प्रकाशित: (2012)

Synthesis of the ABC fragment of pectenotoxin-4
द्वारा: Lipinski, RM
प्रकाशित: (2012)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
द्वारा: Poingdestre, SJ
प्रकाशित: (2012)

Aziridinations of tethered allenes
द्वारा: Feast, GC
प्रकाशित: (2011)

Asymmetric synthesis of piperidine alkaloids
द्वारा: Thomson, A, और अन्य
प्रकाशित: (2012)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
द्वारा: Ye, Y
प्रकाशित: (2013)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
द्वारा: Lenden, P
प्रकाशित: (2011)