Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

<p>High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzyme...

Полное описание

Библиографические подробности
Главный автор:	Williams, J
Другие авторы:	Harris, A
Формат:	Диссертация
Язык:	English
Опубликовано:	2013
Предметы:	Organic synthesis Enzymes Tumours Synthetic organic chemistry Metabolism Oncology

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