MITF-dependent phenotypic plasticity regulates proton-coupled transport and controls lineage resistance to acidotic stress
<p>The lineage addiction oncogene, Microphthalmia-Associated Transcription Factor (MITF), mediates melanoma phenotypic plasticity – a pathophysiological process that underlies intratumoural heterogeneity, where melanoma cells interchangeably alter their phenotypes and transcriptomic gene signa...
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| Format: | Thesis |
| Language: | English |
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2020
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