Investigation of the biological role of iASPP in vivo

Investigation of the biological role of iASPP in vivo

<p>The p53 family of transcription factors, which comprises the products of the TP53, TP63 and TP73 genes, is at the hub of different signalling pathways that determine the fate of a cell. <em>In vitro</em>, the p53 family posses a tumour suppressive function. However, <em>in...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Notari, M
Andre forfattere:	Lu, X
Format:	Thesis
Sprog:	English
Udgivet:	2011
Fag:	Cardiovascular disease Biology Medical Sciences

Lignende værker

Investigating the role of iASPP in cutaneous disorders
af: Dedeić, Z
Udgivet: (2014)

Investigating the role of iASPP and ASPP2 in human carcinoma
af: Salter, V
Udgivet: (2014)

Investigating the role of iASPP in normal prostate development and prostate tumourigenesis
af: Morris, E, et al.
Udgivet: (2013)

Investigating the role of iASPP in skin homeostasis and tumourigenesis
af: Chung, HKK
Udgivet: (2014)

Investigation of the role of ASPP2 in tumourigenesis
af: Tordella, L
Udgivet: (2012)

iASPP in the balance between tolerance and autoimmunity
af: Akama-Garren, E
Udgivet: (2017)

Cardiocutaneous syndrome is caused by aggregation of iASPP mutants
af: Lotz, R, et al.
Udgivet: (2024)

Cardiocutaneous syndrome is caused by aggregation of iASPP mutants
af: Rebecca Lotz, et al.
Udgivet: (2024-12-01)

Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders
af: Dedeić, Z, et al.
Udgivet: (2018)

Nuclear iASPP may facilitate prostate cancer progression.
af: Morris, E, et al.
Udgivet: (2014)

Regulation of immunological tolerance by the p53-inhibitor iASPP
af: Akama-Garren, EH, et al.
Udgivet: (2023)

Regulation of immunological tolerance by the p53-inhibitor iASPP
af: Elliot H. Akama-Garren, et al.
Udgivet: (2023-02-01)

p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
af: Miller, P, et al.
Udgivet: (2023)

iASPP regulates neurite development by interacting with Spectrin proteins
af: Junhao Wang, et al.
Udgivet: (2023-05-01)

Investigating a role of ASPP2 in the cellular response to infection
af: Lim, Y, et al.
Udgivet: (2014)

Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma
af: Ka-Kui Chan, et al.
Udgivet: (2019-10-01)

Effect of iASPP RNAi vector transfection on apoptosis of MCF-7
af: Hou, L, et al.
Udgivet: (2008)

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.
af: Notari, M, et al.
Udgivet: (2011)

iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe.
af: Jiang, L, et al.
Udgivet: (2011)

Effect of RNA interference of iASPP on the apoptosis in MCF-7 breast cancer cells.
af: Liu, Z, et al.
Udgivet: (2008)

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.
af: Bergamaschi, D, et al.
Udgivet: (2003)

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
af: Slee, EA, et al.
Udgivet: (2004)

Cardiosphere-derived stem cell culture, characterisation and labelling for in vivo testing in the infarcted heart
af: Tan, J
Udgivet: (2011)

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
af: Lotz, R, et al.
Udgivet: (2025)

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.
af: Hu, Y, et al.
Udgivet: (2015)

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
af: Rebecca Lotz, et al.
Udgivet: (2025-01-01)

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
af: Mantovani, F, et al.
Udgivet: (2007)

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.
af: Ariel M Wilson, et al.
Udgivet: (2014-01-01)

Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB
af: Wenjie Ge, et al.
Udgivet: (2021-07-01)

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
af: Chen, S, et al.
Udgivet: (2019)

Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis
af: Al Moussawi, K, et al.
Udgivet: (2022)

Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells
af: Shaowei Qiu, et al.
Udgivet: (2017-11-01)

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.
af: Bergamaschi, D, et al.
Udgivet: (2006)

An investigation into the molecular mechanism of the fibrillin1 - LTBP1 interaction
af: Robertson, I, et al.
Udgivet: (2012)

Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models
af: Chun-Yan Wang, et al.
Udgivet: (2020-09-01)

The role of ASPP2 in intestinal homeostasis and tumourigenesis
af: Qin, X
Udgivet: (2017)

High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML)
af: Mihada Bajrami Saipi, et al.
Udgivet: (2024-11-01)

The role of ASPP2 in intestinal cell polarity and homeostasis
af: Morato Koch, S
Udgivet: (2013)

Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.
af: Llanos, S, et al.
Udgivet: (2011)

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
af: Lu, M, et al.
Udgivet: (2013)