Investigation of the biological role of iASPP in vivo

Investigation of the biological role of iASPP in vivo

<p>The p53 family of transcription factors, which comprises the products of the TP53, TP63 and TP73 genes, is at the hub of different signalling pathways that determine the fate of a cell. <em>In vitro</em>, the p53 family posses a tumour suppressive function. However, <em>in...

Podrobná bibliografie
Hlavní autor:	Notari, M
Další autoři:	Lu, X
Médium:	Diplomová práce
Jazyk:	English
Vydáno:	2011
Témata:	Cardiovascular disease Biology Medical Sciences

Podobné jednotky

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iASPP regulates neurite development by interacting with Spectrin proteins
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Effect of iASPP RNAi vector transfection on apoptosis of MCF-7
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Vydáno: (2008)

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.
Autor: Notari, M, a další
Vydáno: (2011)

iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe.
Autor: Jiang, L, a další
Vydáno: (2011)

Effect of RNA interference of iASPP on the apoptosis in MCF-7 breast cancer cells.
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Vydáno: (2008)

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.
Autor: Bergamaschi, D, a další
Vydáno: (2003)

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
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Cardiosphere-derived stem cell culture, characterisation and labelling for in vivo testing in the infarcted heart
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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
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Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.
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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
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Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.
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Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB
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iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
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Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis
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Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells
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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.
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An investigation into the molecular mechanism of the fibrillin1 - LTBP1 interaction
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Vydáno: (2012)

Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models
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The role of ASPP2 in intestinal homeostasis and tumourigenesis
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High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML)
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Vydáno: (2024-11-01)

The role of ASPP2 in intestinal cell polarity and homeostasis
Autor: Morato Koch, S
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Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.
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Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
Autor: Lu, M, a další
Vydáno: (2013)