Investigation of the biological role of iASPP in vivo

Investigation of the biological role of iASPP in vivo

<p>The p53 family of transcription factors, which comprises the products of the TP53, TP63 and TP73 genes, is at the hub of different signalling pathways that determine the fate of a cell. <em>In vitro</em>, the p53 family posses a tumour suppressive function. However, <em>in...

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Bibliografiska uppgifter
Huvudupphovsman:	Notari, M
Övriga upphovsmän:	Lu, X
Materialtyp:	Lärdomsprov
Språk:	English
Publicerad:	2011
Ämnen:	Cardiovascular disease Biology Medical Sciences

Liknande verk

Investigating the role of iASPP in cutaneous disorders
av: Dedeić, Z
Publicerad: (2014)

Investigating the role of iASPP and ASPP2 in human carcinoma
av: Salter, V
Publicerad: (2014)

Investigating the role of iASPP in normal prostate development and prostate tumourigenesis
av: Morris, E, et al.
Publicerad: (2013)

Investigating the role of iASPP in skin homeostasis and tumourigenesis
av: Chung, HKK
Publicerad: (2014)

Investigation of the role of ASPP2 in tumourigenesis
av: Tordella, L
Publicerad: (2012)

iASPP in the balance between tolerance and autoimmunity
av: Akama-Garren, E
Publicerad: (2017)

Cardiocutaneous syndrome is caused by aggregation of iASPP mutants
av: Lotz, R, et al.
Publicerad: (2024)

Cardiocutaneous syndrome is caused by aggregation of iASPP mutants
av: Rebecca Lotz, et al.
Publicerad: (2024-12-01)

Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders
av: Dedeić, Z, et al.
Publicerad: (2018)

Nuclear iASPP may facilitate prostate cancer progression.
av: Morris, E, et al.
Publicerad: (2014)

Regulation of immunological tolerance by the p53-inhibitor iASPP
av: Akama-Garren, EH, et al.
Publicerad: (2023)

Regulation of immunological tolerance by the p53-inhibitor iASPP
av: Elliot H. Akama-Garren, et al.
Publicerad: (2023-02-01)

p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
av: Miller, P, et al.
Publicerad: (2023)

iASPP regulates neurite development by interacting with Spectrin proteins
av: Junhao Wang, et al.
Publicerad: (2023-05-01)

Investigating a role of ASPP2 in the cellular response to infection
av: Lim, Y, et al.
Publicerad: (2014)

Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma
av: Ka-Kui Chan, et al.
Publicerad: (2019-10-01)

Effect of iASPP RNAi vector transfection on apoptosis of MCF-7
av: Hou, L, et al.
Publicerad: (2008)

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.
av: Notari, M, et al.
Publicerad: (2011)

iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe.
av: Jiang, L, et al.
Publicerad: (2011)

Effect of RNA interference of iASPP on the apoptosis in MCF-7 breast cancer cells.
av: Liu, Z, et al.
Publicerad: (2008)

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.
av: Bergamaschi, D, et al.
Publicerad: (2003)

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
av: Slee, EA, et al.
Publicerad: (2004)

Cardiosphere-derived stem cell culture, characterisation and labelling for in vivo testing in the infarcted heart
av: Tan, J
Publicerad: (2011)

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
av: Lotz, R, et al.
Publicerad: (2025)

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.
av: Hu, Y, et al.
Publicerad: (2015)

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
av: Rebecca Lotz, et al.
Publicerad: (2025-01-01)

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
av: Mantovani, F, et al.
Publicerad: (2007)

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.
av: Ariel M Wilson, et al.
Publicerad: (2014-01-01)

Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB
av: Wenjie Ge, et al.
Publicerad: (2021-07-01)

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
av: Chen, S, et al.
Publicerad: (2019)

Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis
av: Al Moussawi, K, et al.
Publicerad: (2022)

Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells
av: Shaowei Qiu, et al.
Publicerad: (2017-11-01)

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.
av: Bergamaschi, D, et al.
Publicerad: (2006)

An investigation into the molecular mechanism of the fibrillin1 - LTBP1 interaction
av: Robertson, I, et al.
Publicerad: (2012)

Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models
av: Chun-Yan Wang, et al.
Publicerad: (2020-09-01)

The role of ASPP2 in intestinal homeostasis and tumourigenesis
av: Qin, X
Publicerad: (2017)

High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML)
av: Mihada Bajrami Saipi, et al.
Publicerad: (2024-11-01)

The role of ASPP2 in intestinal cell polarity and homeostasis
av: Morato Koch, S
Publicerad: (2013)

Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.
av: Llanos, S, et al.
Publicerad: (2011)

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
av: Lu, M, et al.
Publicerad: (2013)