The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response

The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577...

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Bibliographic Details
Main Authors:	Zhu, L, Pluijm, RVD, Kucharski, M, Nayak, S, Tripathi, J, Nosten, F, Faiz, A, Amaratunga, C, Lek, D, Ashley, E, Smithuis, F, Phyo, AP, Lin, K, Imwong, M, Mayxay, M, Dhorda, M, Chau, NH, Thuy, NNTT, Newton, P, Jittamala, P, Tripura, R, Pukrittayakamee, S, Peto, T, Miotto, O, von Seidlein, L, Hien, TT, Ginsburg, H, Day, NPJ, White, N, Dondorp, A, Bozdech, Z
Format:	Working paper
Language:	English
Published:	bioRxiv 2021

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response

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