The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577...
| Váldodahkkit: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Materiálatiipa: | Working paper |
| Giella: | English |
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bioRxiv
2021
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| _version_ | 1826312561247649792 |
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| author | Zhu, L Pluijm, RVD Kucharski, M Nayak, S Tripathi, J Nosten, F Faiz, A Amaratunga, C Lek, D Ashley, E Smithuis, F Phyo, AP Lin, K Imwong, M Mayxay, M Dhorda, M Chau, NH Thuy, NNTT Newton, P Jittamala, P Tripura, R Pukrittayakamee, S Peto, T Miotto, O von Seidlein, L Hien, TT Ginsburg, H Day, NPJ White, N Dondorp, A Bozdech, Z |
| author_facet | Zhu, L Pluijm, RVD Kucharski, M Nayak, S Tripathi, J Nosten, F Faiz, A Amaratunga, C Lek, D Ashley, E Smithuis, F Phyo, AP Lin, K Imwong, M Mayxay, M Dhorda, M Chau, NH Thuy, NNTT Newton, P Jittamala, P Tripura, R Pukrittayakamee, S Peto, T Miotto, O von Seidlein, L Hien, TT Ginsburg, H Day, NPJ White, N Dondorp, A Bozdech, Z |
| author_sort | Zhu, L |
| collection | OXFORD |
| description | The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodeling and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. |
| first_indexed | 2024-03-07T08:12:45Z |
| format | Working paper |
| id | oxford-uuid:7fd096bf-cc9f-4b97-a9d6-738df37bd58d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:56:54Z |
| publishDate | 2021 |
| publisher | bioRxiv |
| record_format | dspace |
| spelling | oxford-uuid:7fd096bf-cc9f-4b97-a9d6-738df37bd58d2024-03-21T14:41:20ZThe mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional responseWorking paperhttp://purl.org/coar/resource_type/c_8042uuid:7fd096bf-cc9f-4b97-a9d6-738df37bd58dEnglishSymplectic ElementsbioRxiv2021Zhu, LPluijm, RVDKucharski, MNayak, STripathi, JNosten, FFaiz, AAmaratunga, CLek, DAshley, ESmithuis, FPhyo, APLin, KImwong, MMayxay, MDhorda, MChau, NHThuy, NNTTNewton, PJittamala, PTripura, RPukrittayakamee, SPeto, TMiotto, Ovon Seidlein, LHien, TTGinsburg, HDay, NPJWhite, NDondorp, ABozdech, ZThe emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodeling and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. |
| spellingShingle | Zhu, L Pluijm, RVD Kucharski, M Nayak, S Tripathi, J Nosten, F Faiz, A Amaratunga, C Lek, D Ashley, E Smithuis, F Phyo, AP Lin, K Imwong, M Mayxay, M Dhorda, M Chau, NH Thuy, NNTT Newton, P Jittamala, P Tripura, R Pukrittayakamee, S Peto, T Miotto, O von Seidlein, L Hien, TT Ginsburg, H Day, NPJ White, N Dondorp, A Bozdech, Z The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response |
| title | The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response |
| title_full | The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response |
| title_fullStr | The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response |
| title_full_unstemmed | The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response |
| title_short | The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response |
| title_sort | mechanism of artemisinin resistance of plasmodium falciparum malaria parasites originates in their initial transcriptional response |
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