Activation of the HIF pathway in cancer.
The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common canc...
| Main Authors: | , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2001
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| _version_ | 1826281610267328512 |
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| author | Maxwell, P Pugh, C Ratcliffe, P |
| author_facet | Maxwell, P Pugh, C Ratcliffe, P |
| author_sort | Maxwell, P |
| collection | OXFORD |
| description | The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common cancers. This occurs both by genetic mechanisms and through microenvironmental hypoxia. Activation of the HIF pathway has important effects on patterns of gene expression in tumours. |
| first_indexed | 2024-03-07T00:31:23Z |
| format | Journal article |
| id | oxford-uuid:7fea33c9-959d-4f30-9767-bb2b6efb0f30 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:31:23Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:7fea33c9-959d-4f30-9767-bb2b6efb0f302022-03-26T21:19:56ZActivation of the HIF pathway in cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7fea33c9-959d-4f30-9767-bb2b6efb0f30EnglishSymplectic Elements at Oxford2001Maxwell, PPugh, CRatcliffe, PThe maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common cancers. This occurs both by genetic mechanisms and through microenvironmental hypoxia. Activation of the HIF pathway has important effects on patterns of gene expression in tumours. |
| spellingShingle | Maxwell, P Pugh, C Ratcliffe, P Activation of the HIF pathway in cancer. |
| title | Activation of the HIF pathway in cancer. |
| title_full | Activation of the HIF pathway in cancer. |
| title_fullStr | Activation of the HIF pathway in cancer. |
| title_full_unstemmed | Activation of the HIF pathway in cancer. |
| title_short | Activation of the HIF pathway in cancer. |
| title_sort | activation of the hif pathway in cancer |
| work_keys_str_mv | AT maxwellp activationofthehifpathwayincancer AT pughc activationofthehifpathwayincancer AT ratcliffep activationofthehifpathwayincancer |