Activation of the HIF pathway in cancer.

Activation of the HIF pathway in cancer.

The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common canc...

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Bibliografiske detaljer
Main Authors:	Maxwell, P, Pugh, C, Ratcliffe, P
Format:	Journal article
Sprog:	English
Udgivet:	2001

Lignende værker

The HIF pathway: implications for patterns of gene expression in cancer.
af: Wykoff, C, et al.
Udgivet: (2001)

Targeting tumors through the HIF system.
af: Ratcliffe, P, et al.
Udgivet: (2000)

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
af: Maxwell, P, et al.
Udgivet: (2001)

Hypoxia and HIF pathway in cancer and the placenta
af: Macklin, P, et al.
Udgivet: (2017)

Regulation of angiogenesis by hypoxia: role of the HIF system.
af: Pugh, C, et al.
Udgivet: (2003)

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
af: Mole, D, et al.
Udgivet: (2001)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
af: Talks, K, et al.
Udgivet: (2000)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
af: Mole, D, et al.
Udgivet: (2002)

The HIF hydroxylase pathway and the tumour microenvironment
af: Ratcliffe, P
Udgivet: (2008)

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
af: Pugh, C, et al.
Udgivet: (2003)

Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor.
af: Vaux, E, et al.
Udgivet: (2001)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
af: Tuckerman, JR, et al.
Udgivet: (2004)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
af: Wood, S, et al.
Udgivet: (1998)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
af: McNeill, L, et al.
Udgivet: (2002)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
af: Raval, R, et al.
Udgivet: (2005)

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
af: Kaelin, W, et al.
Udgivet: (2008)

HIF-1 and HIF-2: working alone or together in hypoxia?
af: Ratcliffe, P
Udgivet: (2007)

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation.
af: Formenti, F, et al.
Udgivet: (2011)

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
af: Hon, W, et al.
Udgivet: (2002)

Genetic insights into the hypoxia-inducible factor (HIF) pathway.
af: Kiriakidis, S, et al.
Udgivet: (2007)

Oxygen sensing by HIF hydroxylases.
af: Schofield, C, et al.
Udgivet: (2004)

Signalling hypoxia by HIF hydroxylases.
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Udgivet: (2005)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
af: Elkins, J, et al.
Udgivet: (2003)

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
af: Grampp, S, et al.
Udgivet: (2017)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
af: Mole, D, et al.
Udgivet: (2003)

ExCITED about HIF.
af: Bhattacharya, S, et al.
Udgivet: (2003)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
af: Willam, C, et al.
Udgivet: (2006)

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
af: Schödel, J, et al.
Udgivet: (2011)

Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature
af: Lombardi, O, et al.
Udgivet: (2022)

New horizons in hypoxia signaling pathways
af: Pugh, C, et al.
Udgivet: (2017)

Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites.
af: Nagao, M, et al.
Udgivet: (1996)

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
af: Steffen Grampp, et al.
Udgivet: (2017-07-01)

HIF hydroxylation and cellular oxygen sensing.
af: Metzen, E, et al.
Udgivet: (2004)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
af: Schlemminger, I, et al.
Udgivet: (2003)

Regulation of HIF: prolyl hydroxylases.
af: Stolze, I, et al.
Udgivet: (2006)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
af: Webb, J, et al.
Udgivet: (2009)

ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer
af: Feng He, et al.
Udgivet: (2021-05-01)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
af: Cockman, M, et al.
Udgivet: (2019)

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.
af: Morris, MR, et al.
Udgivet: (2009)

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
af: Wiesener, MS, et al.
Udgivet: (2003)