Activation of the HIF pathway in cancer.

The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common canc...

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Hlavní autoři: Maxwell, P, Pugh, C, Ratcliffe, P
Médium: Journal article
Jazyk:English
Vydáno: 2001