Investigation of single-drug-encapsulating liposomes using the nano-impact method.

Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano-impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposome...

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Detalles Bibliográficos
Main Authors: Cheng, W, Compton, R
Formato: Journal article
Idioma:English
Publicado: 2014
Descripción
Summary:Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano-impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time.