A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes
β-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such s...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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