A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.

Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current therapeutic and preventative options are to be extended. To identify diabetes-susceptibility genes, we have completed a primary (418-marker, 9-cM) autosomal-genome scan of 743 sib pairs (573 pedigrees) wi...

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Библиографические подробности
Главные авторы: Wiltshire, S, Hattersley, A, Hitman, G, Walker, M, Levy, J, Sampson, M, O'Rahilly, S, Frayling, T, Bell, J, Lathrop, G, Bennett, A, Dhillon, R, Fletcher, C, Groves, C, Jones, E, Prestwich, P, Simecek, N, Rao, P, Wishart, M, Bottazzo, G, Foxon, R, Howell, S, Smedley, D, Cardon, L, Menzel, S
Формат: Journal article
Язык:English
Опубликовано: 2001

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