The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

Regulatory T cells (Tregs) have a central role in maintaining immune homoeostasis through various mechanisms. Although the Forkhead transcription factor Foxp3 defines the Treg cell lineage and functions, the molecular mechanisms of Foxp3 induction and maintenance remain elusive. Here we show that Fo...

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Những tác giả chính: Sekiya, T, Kashiwagi, I, Inoue, N, Morita, R, Hori, S, Waldmann, H, Rudensky, A, Ichinose, H, Metzger, D, Chambon, P, Yoshimura, A
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Springer Nature 2011