Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation

Vaccines against N.meningitidis have been developed from the plain capsular polysaccharide, (T-independent antigen), and by covalently linking the polysaccharide to a protein carrier to from a polysaccharide-protein conjugate (T-dependent antigen). To investigate differences in the immune response t...

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Bibliographic Details
Main Authors: Galson, J, Clutterbuck, E, Trueck, J, Muenz, M, Fowler, A, Cerundolo, V, Pollard, A, Lunter, G, Kelly, D
Format: Journal article
Published: Wiley 2014