Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation
Vaccines against N.meningitidis have been developed from the plain capsular polysaccharide, (T-independent antigen), and by covalently linking the polysaccharide to a protein carrier to from a polysaccharide-protein conjugate (T-dependent antigen). To investigate differences in the immune response t...
| Hlavní autoři: | , , , , , , , , |
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| Médium: | Journal article |
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Wiley
2014
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| _version_ | 1826281713993515008 |
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| author | Galson, J Clutterbuck, E Trueck, J Muenz, M Fowler, A Cerundolo, V Pollard, A Lunter, G Kelly, D |
| author_facet | Galson, J Clutterbuck, E Trueck, J Muenz, M Fowler, A Cerundolo, V Pollard, A Lunter, G Kelly, D |
| author_sort | Galson, J |
| collection | OXFORD |
| description | Vaccines against N.meningitidis have been developed from the plain capsular polysaccharide, (T-independent antigen), and by covalently linking the polysaccharide to a protein carrier to from a polysaccharide-protein conjugate (T-dependent antigen). To investigate differences in the immune response to these two vaccine types, plasma cells were isolated 7 days following administration of meningococcal serogroup ACWY polysaccharide and conjugate vaccines. Additionally, naïve, marginal zone, IgM memory and IgG memory B cell subsets were isolated at baseline. Next-generation sequencing was used to obtain B cell receptor sequence data from all populations. |
| first_indexed | 2024-03-07T00:32:57Z |
| format | Journal article |
| id | oxford-uuid:8071a218-fcf4-4eee-8b0b-1e37c40d1a4e |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:32:57Z |
| publishDate | 2014 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:8071a218-fcf4-4eee-8b0b-1e37c40d1a4e2022-03-26T21:23:21ZPlasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8071a218-fcf4-4eee-8b0b-1e37c40d1a4eSymplectic Elements at OxfordWiley2014Galson, JClutterbuck, ETrueck, JMuenz, MFowler, ACerundolo, VPollard, ALunter, GKelly, DVaccines against N.meningitidis have been developed from the plain capsular polysaccharide, (T-independent antigen), and by covalently linking the polysaccharide to a protein carrier to from a polysaccharide-protein conjugate (T-dependent antigen). To investigate differences in the immune response to these two vaccine types, plasma cells were isolated 7 days following administration of meningococcal serogroup ACWY polysaccharide and conjugate vaccines. Additionally, naïve, marginal zone, IgM memory and IgG memory B cell subsets were isolated at baseline. Next-generation sequencing was used to obtain B cell receptor sequence data from all populations. |
| spellingShingle | Galson, J Clutterbuck, E Trueck, J Muenz, M Fowler, A Cerundolo, V Pollard, A Lunter, G Kelly, D Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation |
| title | Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation |
| title_full | Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation |
| title_fullStr | Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation |
| title_full_unstemmed | Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation |
| title_short | Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation |
| title_sort | plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein polysaccharide conjugate vaccines evidence of distinct patterns of b cell activation |
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