Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin- mediated endothelial nitric oxide synthase coupling

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin- mediated endothelial nitric oxide synthase coupling

Ցույց տալ այլ տարբերակներ (1)

Background-: Treatment with statins improves clinical outcome, but the exact mechanisms of pleiotropic statin effects on vascular function in human atherosclerosis remain unclear. We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase co...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Antoniades, C, Bakogiannis, C, Leeson, P, Guzik, T, Zhang, M, Tousoulis, D, Antonopoulos, A, Demosthenous, M, Marinou, K, Hale, A, Paschalis, A, Psarros, C, Triantafyllou, C, Bendall, J, Casadei, B, Stefanadis, C, Channon, K
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	2011

Նմանատիպ նյութեր

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

Statin treatment improves vascular redox state through a tetrahydrobiopterin-mediated re-coupling of endothelial nitric oxide synthase, in human atherosclerosis
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

RAPID, DIRECT EFFECTS OF STATIN TREATMENT ON ARTERIAL REDOX STATE AND NITRIC OXIDE BIOAVAILABILITY IN HUMAN ATHEROSCLEROSIS VIA TETRAHYDROBIOPTERIN-MEDIATED ENOS COUPLING
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

Atorvastatin rapidly modifies vascular redox state and improves nitric oxide bioavailability in human vessels obtained from patients with advanced atherosclerosis
‌: Demosthenous, M, և այլն
Հրապարակվել է: (2010)

Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

Myocardial Redox State Predicts Post-Operative Clinical Outcome in Patients Undergoing Elective CABG: The Role of NADPH-Oxidase and Uncoupled Nitric Oxide Synthase
‌: Antoniades, C, և այլն
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Mechanisms regulating myocardial redox state in chronic atrial fibrillation: the role of NADPH-oxidase and uncoupled nitric oxide synthases
‌: Margaritis, M, և այլն
Հրապարակվել է: (2010)

Endothelial nitric oxide synthase in the vascular wall: Mechanisms regulating its expression and enzymatic function
‌: Demosthenous, M, և այլն
Հրապարակվել է: (2011)

Endothelial nitric oxide synthase in the vascular wall: Mechanisms regulating its expression and enzymatic function
‌: Demosthenous, M, և այլն
Հրապարակվել է: (2011)

Plasma asymmetrical-dimethyl-arginine (ADMA) regulates nitric oxide bioavailability and vascular superoxide production in human vessels
‌: Antoniades, C, և այլն
Հրապարակվել է: (2007)

Tetrahydrobiopterin and nitric oxide synthase recouplers
‌: Channon, KM
Հրապարակվել է: (2020)

Plasma asymmetrical-dimethyl-arginine (ADMA) as a regulator of vascular redox and nitric oxide bioavailability in human vessels
‌: Antoniades, C, և այլն
Հրապարակվել է: (2007)

Short-Term Atorvastatin Treatment Reduces Vascular Oxidative Stress Saphenous Vein Grafts by Improving eNOS Coupling and Reducing NADPH-Oxidase Activity in Patients Undergoing Elective CABG
‌: Antoniades, C, և այլն
Հրապարակվել է: (2009)

Nitric oxide-releasing aspirin: will it say NO to atherothrombosis?
‌: Antoniades, C, և այլն
Հրապարակվել է: (2007)

Plasma asymmetrical-dimethyl-arginine affects eNOS vascular superoxide radical production and nitric oxide bioavailability in human arteries and veins
‌: Antoniades, C, և այլն
Հրապարակվել է: (2008)

Nitric oxide in coronary artery disease: Effects of antioxidants
‌: Tousoulis, D, և այլն
Հրապարակվել է: (2006)

Endothelial nitric oxide synthase in the vascular wall: Mechanisms regulating its expression and enzymatic function
‌: Michael Demosthenous, և այլն
Հրապարակվել է: (2011-04-01)

Oral Atorvastatin Treatment Improves NO Bioavailability and Vascular Redox State in the Human Arterial Wall, via a Tetrahydrobiopterin-Mediated Improvement of eNOS Coupling
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)

Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
‌: Antoniades, C, և այլն
Հրապարակվել է: (2008)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
‌: Khoo, J, և այլն
Հրապարակվել է: (2004)

5-methyl-tetrahydrofolic acid increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling in human vessels in vivo: Effects on intracellular tetrahydrobiopterin oxidation
‌: Antoniades, C, և այլն
Հրապարակվել է: (2006)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
‌: Channon, K
Հրապարակվել է: (2004)

Tetrahydrobiopterin: coupling nitric oxide and redox signalling in cardiovascular disease
‌: Channon, K
Հրապարակվել է: (2012)

Genetic Polymorphism On Methyl-Tetrahydrofolate-Reductase Affects Vascular Superoxide Generation and Nitric Oxide Bioavailability By Regulating eNOS Coupling in Human Arteries and Veins
‌: Antoniades, C, և այլն
Հրապարակվել է: (2009)

Adiponectin as a Biomarker at Different Stages of Ischaemic Heart Disease: From Obesity to Ischaemic Heart Failure
‌: Antonopoulos, A, և այլն
Հրապարակվել է: (2009)

Genetic variability of MTHFR affects vascular redox and nitric oxide bioavailability in human vessels, by modifying eNOS coupling
‌: Antoniades, C, և այլն
Հրապարակվել է: (2008)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
‌: Alp, N, և այլն
Հրապարակվել է: (2004)

Interrelationships between vascular superoxide and adiponectin biosynthesis in perivascular adipose tissue in human atherosclerosis
‌: Bakogiannis, C, և այլն
Հրապարակվել է: (2010)

Acute Inflammation Rapidly Increases Plasma Biopterins and Impairs Endothelial Function: A Novel Role of Plasma Tetrahydrobiopterin as a Marker of Acute Inflammation
‌: Antonopoulos, A, և այլն
Հրապարակվել է: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
‌: Crabtree, M, և այլն
Հրապարակվել է: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
‌: Crabtree, M, և այլն
Հրապարակվել է: (2011)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
‌: Alp, N, և այլն
Հրապարակվել է: (2003)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
‌: Juni, R, և այլն
Հրապարակվել է: (2012)

Effects of endothelial nitric oxide synthase gene polymorphisms on oxidative stress, inflammatory status, and coronary atherosclerosis: an example of a transient phenotype.
‌: Antoniades, C, և այլն
Հրապարակվել է: (2007)

Statins ameliorate atherosclerosis induced by inhibition of nitric oxide synthase: another novel vascular protective mechanism?
‌: Tousoulis, D, և այլն
Հրապարակվել է: (2008)

Novel therapeutic strategies targeting vascular redox in human atherosclerosis.
‌: Antonopoulos, A, և այլն
Հրապարակվել է: (2009)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
‌: Khoo, J, և այլն
Հրապարակվել է: (2005)

Haplotype on GTP-Cyclohydrolase I Gene, Reveals a Novel Role of Tetrahydrobiopterin as a Defense Mechanism Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis
‌: Antoniades, C, և այլն
Հրապարակվել է: (2011)