Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.

Recent multi-dimensional approaches to the study of complex disease have revealed powerful insights into how genetic and epigenetic factors may underlie their aetiopathogenesis. We examined genotype-epigenotype interactions in the context of Type 2 Diabetes (T2D), focussing on known regions of genom...

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Príomhchruthaitheoirí: Bell, C, Finer, S, Lindgren, C, Wilson, G, Rakyan, V, Teschendorff, A, Akan, P, Stupka, E, Down, T, Prokopenko, I, Morison, I, Mill, J, Pidsley, R, Deloukas, P, Frayling, T, Hattersley, A, McCarthy, M, Beck, S, Hitman, G
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2010