The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

<p>Two-pore-domain potassium (K<sub>2P</sub>) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs preferentially bind to a...

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מידע ביבליוגרפי
Main Authors: Rinné, S, Kiper, A, Vowinkel, K, Ramírez, D, Schewe, M, Bedoya, M, Aser, D, Gensler, I, Netter, M, Stansfeld, P, Baukrowitz, T, Gonzalez, W, Decher, N
פורמט: Journal article
שפה:English
יצא לאור: eLife Sciences Publications 2019