The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels
<p>Two-pore-domain potassium (K<sub>2P</sub>) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs preferentially bind to a...
मुख्य लेखकों: | Rinné, S, Kiper, A, Vowinkel, K, Ramírez, D, Schewe, M, Bedoya, M, Aser, D, Gensler, I, Netter, M, Stansfeld, P, Baukrowitz, T, Gonzalez, W, Decher, N |
---|---|
स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
eLife Sciences Publications
2019
|
समान संसाधन
-
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
द्वारा: Schewe, M, और अन्य
प्रकाशित: (2019) -
Structural and Mechanistic Insights into Gating of K2P Channels
द्वारा: Rapedius, M, और अन्य
प्रकाशित: (2012) -
The pore structure and gating mechanism of K2P channels
द्वारा: Piechotta, P, और अन्य
प्रकाशित: (2011) -
The pore structure and gating mechanism of K2P channels.
द्वारा: Piechotta, P, और अन्य
प्रकाशित: (2011) -
A novel mechanism of voltage sensing and gating in K2P potassium channels
द्वारा: Schewe, M, और अन्य
प्रकाशित: (2014)