Nicotinamide cofactors suppress active-site labeling of aldehyde dehydrogenases

Active site labeling by (re)activity-based probes is a powerful chemical proteomic tool to globally map active sites in native proteomes without using substrates. Active site labeling is usually taken as a readout for the active state of the enzyme because labeling reflects the availability and reac...

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Bibliographic Details
Main Authors: Stiti, N, Chandrasekar, B, Strubl, L, Mohammed, S, Bartels, D, van der Hoorn, R
Format: Journal article
Language:English
Published: American Chemical Society 2016