Activation of central orexin/hypocretin neurons by dietary amino acids.

Hypothalamic orexin/hypocretin (orx/hcrt) neurons regulate energy balance, wakefulness, and reward; their loss produces narcolepsy and weight gain. Glucose can lower the activity of orx/hcrt cells, but whether other dietary macronutrients have similar effects is unclear. We show that orx/hcrt cells...

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Bibliographic Details
Main Authors: Karnani, M, Apergis-Schoute, J, Adamantidis, A, Jensen, LT, de Lecea, L, Fugger, L, Burdakov, D
Format: Journal article
Language:English
Published: 2011