Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?

Resistance to the antifolate sulfadoxine-pyrimethamine (SP), the current mass-treatment antimalarial drug, is associated with selection of point mutations in dihydrofolate reductase and dihydropteroate synthase. Among these mutations, the leucine 164 dihydrofolate reductase mutation (Leu-164) is ass...

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Váldodahkkit: Nzila, A, Ochong, E, Nduati, E, Gilbert, K, Winstanley, P, Ward, S, Marsh, K
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2005