HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Chronic infections in mice can result in defects in memory CD8 T cell properties including low expression of the IL-7Ralpha (CD127). To determine whether defects in memory CD8 T cell formation exist during human chronic infections and to what extent these defects may be allele- or epitope-specific,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797078764399624192 |
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| author | Wherry, E Day, C Draenert, R Miller, J Kiepiela, P Woodberry, T Brander, C Addo, M Klenerman, P Ahmed, R Walker, B |
| author_facet | Wherry, E Day, C Draenert, R Miller, J Kiepiela, P Woodberry, T Brander, C Addo, M Klenerman, P Ahmed, R Walker, B |
| author_sort | Wherry, E |
| collection | OXFORD |
| description | Chronic infections in mice can result in defects in memory CD8 T cell properties including low expression of the IL-7Ralpha (CD127). To determine whether defects in memory CD8 T cell formation exist during human chronic infections and to what extent these defects may be allele- or epitope-specific, we compared influenza (Flu), vaccinia (VV) and EBV-specific CD8 T cells to HIV-specific CD8 T cells, using a panel of 13 HIV tetramers. Compared to Flu, VV or EBV, HIV tetramer+ CD8 T cells expressed significantly lower levels of CD127, and this reduction was pervasive across all epitopes and alleles tested and over a wide range of viral loads and CD4 counts. These results indicate impaired HIV-specific memory CD8 T cell differentiation, regardless of level of control of viremia, epitopes targeted or restricting HLA alleles. |
| first_indexed | 2024-03-07T00:36:23Z |
| format | Journal article |
| id | oxford-uuid:819035da-daa2-416d-a916-ebb5cc1fbef9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:36:23Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:819035da-daa2-416d-a916-ebb5cc1fbef92022-03-26T21:31:04ZHIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:819035da-daa2-416d-a916-ebb5cc1fbef9EnglishSymplectic Elements at Oxford2006Wherry, EDay, CDraenert, RMiller, JKiepiela, PWoodberry, TBrander, CAddo, MKlenerman, PAhmed, RWalker, BChronic infections in mice can result in defects in memory CD8 T cell properties including low expression of the IL-7Ralpha (CD127). To determine whether defects in memory CD8 T cell formation exist during human chronic infections and to what extent these defects may be allele- or epitope-specific, we compared influenza (Flu), vaccinia (VV) and EBV-specific CD8 T cells to HIV-specific CD8 T cells, using a panel of 13 HIV tetramers. Compared to Flu, VV or EBV, HIV tetramer+ CD8 T cells expressed significantly lower levels of CD127, and this reduction was pervasive across all epitopes and alleles tested and over a wide range of viral loads and CD4 counts. These results indicate impaired HIV-specific memory CD8 T cell differentiation, regardless of level of control of viremia, epitopes targeted or restricting HLA alleles. |
| spellingShingle | Wherry, E Day, C Draenert, R Miller, J Kiepiela, P Woodberry, T Brander, C Addo, M Klenerman, P Ahmed, R Walker, B HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. |
| title | HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. |
| title_full | HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. |
| title_fullStr | HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. |
| title_full_unstemmed | HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. |
| title_short | HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. |
| title_sort | hiv specific cd8 t cells express low levels of il 7ralpha implications for hiv specific t cell memory |
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