Simulation studies of surrogate endpoint validation using single trial and multitrial statistical approaches.

OBJECTIVE: A schema was recently proposed for assessing the levels of evidence for surrogate validity that included 4 domains: Target, Study Design, Statistical Strength, and Penalties. This report examines one component of the schema. It surveys the literature on methods of statistical validation...

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Bibliographic Details
Main Authors: Lassere, M, Johnson, K, Hughes, M, Altman, D, Buyse, M, Galbraith, S, Wells, G
Format: Conference item
Published: 2007