Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates.

Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates.

The sensitization of spinal dorsal horn neurones leads to prolonged enhancement of pain behaviour and can be evoked by intense C-fibre stimulation, tissue inflammation and peripheral nerve injury. Activation of central immune cells plays a key role in establishing pain hypersensitivity but the exact...

Полное описание

Библиографические подробности
Главные авторы:	Hathway, G, Vega-Avelaira, D, Moss, A, Ingram, R, Fitzgerald, M
Формат:	Journal article
Язык:	English
Опубликовано:	2009

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