ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY

Taispeáin leaganacha eile (1)

Incubation of L-δ-(α-aminoadipoyl)-L-(3,3-difluorohomocysteinyl)-D-valine [an analogue of the natural substrate: L-δ-(α-aminoadipoyl)-L-(cysteinyl)-D-valine] with isopenicillin N synthase (IPNS) resulted in the production of a thiocarboxylic acid, i.e. both equivalents of the dioxygen cosubstrate we...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Baldwin, J, Lynch, G, Schofield, C
Formáid:	Journal article
Foilsithe / Cruthaithe:	1992

Míreanna comhchosúla

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1991)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
de réir: Randall, C, et al.
Foilsithe / Cruthaithe: (1992)

FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1989)

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1988)

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
de réir: Aplin, RT, et al.
Foilsithe / Cruthaithe: (1990)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
de réir: Roach, P, et al.
Foilsithe / Cruthaithe: (1997)

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
de réir: Sami, M, et al.
Foilsithe / Cruthaithe: (1997)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
de réir: Roach, P, et al.
Foilsithe / Cruthaithe: (1995)

Mechanistic studies on isopenicillin n synthase
de réir: Abbott, S
Foilsithe / Cruthaithe: (1991)

Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins
de réir: Cavelier, F, et al.
Foilsithe / Cruthaithe: (1997)

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
de réir: Dubus, A, et al.
Foilsithe / Cruthaithe: (2000)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
de réir: Daruzzaman, A, et al.
Foilsithe / Cruthaithe: (2013)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
de réir: Roach, P, et al.
Foilsithe / Cruthaithe: (1995)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
de réir: Rabe, P, et al.
Foilsithe / Cruthaithe: (2018)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
de réir: Fujishima, Y, et al.
Foilsithe / Cruthaithe: (1994)

Modification of iron binding ligands in isopenicillin n synthase
de réir: Sami, M, et al.
Foilsithe / Cruthaithe: (1998)

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
de réir: Randall, C, et al.
Foilsithe / Cruthaithe: (1993)

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
de réir: Roach, P, et al.
Foilsithe / Cruthaithe: (1996)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
de réir: Ge, W, et al.
Foilsithe / Cruthaithe: (2010)

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
de réir: Ge, W, et al.
Foilsithe / Cruthaithe: (2009)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
de réir: Ge, W, et al.
Foilsithe / Cruthaithe: (2010)

Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases
de réir: McNeill, LA, et al.
Foilsithe / Cruthaithe: (2017)

Photoaffinity labelling of isopenicillin N synthetase.
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1990)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
de réir: Long, A, et al.
Foilsithe / Cruthaithe: (2003)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
de réir: Roach, P, et al.
Foilsithe / Cruthaithe: (1996)

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
de réir: Clifton, I, et al.
Foilsithe / Cruthaithe: (2011)

Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1989)

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?
de réir: Ge, W, et al.
Foilsithe / Cruthaithe: (2008)

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
de réir: Rabe, P, et al.
Foilsithe / Cruthaithe: (2022)

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.
de réir: Clifton, I, et al.
Foilsithe / Cruthaithe: (2011)

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
de réir: Daruzzaman, A, et al.
Foilsithe / Cruthaithe: (2013)

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
de réir: Rabe, P, et al.
Foilsithe / Cruthaithe: (2021)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
de réir: Long, A, et al.
Foilsithe / Cruthaithe: (2005)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
de réir: Aplin, RT, et al.
Foilsithe / Cruthaithe: (1993)

Analysis of the conversion of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate by active-site mutants of Aspergillus nidulans isopenicillin N synthase.
de réir: Rowe, C, et al.
Foilsithe / Cruthaithe: (1998)

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.
de réir: Hamed, R, et al.
Foilsithe / Cruthaithe: (2010)

THE SYNTHESIS OF ARYL SUBSTITUTED ANALOGS OF PHENOXYACETYL-L-CYSTEINYL-D-VALINE AND PHENYLACETYL-L-CYSTEINYL-D-VALINE - APPLICATION TO THE PHOTOAFFINITY-LABELING OF ISOPENICILLIN N SYNTHETASE
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1987)

Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase.
de réir: Baldwin, J, et al.
Foilsithe / Cruthaithe: (1992)

Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)
de réir: Shibata, N, et al.
Foilsithe / Cruthaithe: (1996)

Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.
de réir: Caines, M, et al.
Foilsithe / Cruthaithe: (2009)