Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes
Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulati...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2016
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| _version_ | 1797078983484899328 |
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| author | Verrier, E Colpitts, C Bach, C Heydmann, L Zona, L Xiao, F Thumann, C Crouchet, E Gaudin, R Sureau, C Cosset, F McKeating, J Pessaux, P Hoshida, Y Schuster, C Zeisel, M Baumert, T |
| author_facet | Verrier, E Colpitts, C Bach, C Heydmann, L Zona, L Xiao, F Thumann, C Crouchet, E Gaudin, R Sureau, C Cosset, F McKeating, J Pessaux, P Hoshida, Y Schuster, C Zeisel, M Baumert, T |
| author_sort | Verrier, E |
| collection | OXFORD |
| description | Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection of hepatocytes and is relevant for cell-to-cell transmission. NTCP regulates HCV infection by augmenting the bile-acid-mediated repression of interferon-stimulated genes (ISGs), including IFITM3. In conclusion, our results uncover NTCP as a mediator of innate antiviral immune responses in the liver, and they establish a role for NTCP in the infection process of multiple viruses via distinct mechanisms. Collectively, our findings suggest a role for solute carriers in the regulation of innate antiviral responses, and they have potential implications for virus-host interactions and antiviral therapies. |
| first_indexed | 2024-03-07T00:39:09Z |
| format | Journal article |
| id | oxford-uuid:8273d524-f067-45f3-a68a-5f0be79cf5fc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:39:09Z |
| publishDate | 2016 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:8273d524-f067-45f3-a68a-5f0be79cf5fc2022-03-26T21:37:28ZSolute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of HepatocytesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8273d524-f067-45f3-a68a-5f0be79cf5fcEnglishSymplectic Elements at OxfordCell Press2016Verrier, EColpitts, CBach, CHeydmann, LZona, LXiao, FThumann, CCrouchet, EGaudin, RSureau, CCosset, FMcKeating, JPessaux, PHoshida, YSchuster, CZeisel, MBaumert, TChronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection of hepatocytes and is relevant for cell-to-cell transmission. NTCP regulates HCV infection by augmenting the bile-acid-mediated repression of interferon-stimulated genes (ISGs), including IFITM3. In conclusion, our results uncover NTCP as a mediator of innate antiviral immune responses in the liver, and they establish a role for NTCP in the infection process of multiple viruses via distinct mechanisms. Collectively, our findings suggest a role for solute carriers in the regulation of innate antiviral responses, and they have potential implications for virus-host interactions and antiviral therapies. |
| spellingShingle | Verrier, E Colpitts, C Bach, C Heydmann, L Zona, L Xiao, F Thumann, C Crouchet, E Gaudin, R Sureau, C Cosset, F McKeating, J Pessaux, P Hoshida, Y Schuster, C Zeisel, M Baumert, T Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes |
| title | Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes |
| title_full | Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes |
| title_fullStr | Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes |
| title_full_unstemmed | Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes |
| title_short | Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes |
| title_sort | solute carrier ntcp regulates innate antiviral immune responses targeting hepatitis c virus infection of hepatocytes |
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