A role for APP in Wnt signalling links synapse loss with β-amyloid production

A role for APP in Wnt signalling links synapse loss with β-amyloid production

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synaps...

Podrobná bibliografie
Hlavní autoři:	Elliott, C, Rojo, A, Ribe, E, Broadstock, M, Xia, W, Morin, P, Semenov, M, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, C, Simons, P, Killick, R
Médium:	Journal article
Vydáno:	Springer Nature 2018

Podobné jednotky

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
Autor: Sellers, K, a další
Vydáno: (2017)

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses
Autor: Hilla Fogel, a další
Vydáno: (2014-06-01)

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP
Autor: Peter J Morin, a další
Vydáno: (2004-06-01)

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses
Autor: Claudia G. Almeida, a další
Vydáno: (2005-11-01)

Amyloids: Regulators of Metal Homeostasis in the Synapse
Autor: Masahiro Kawahara, a další
Vydáno: (2020-03-01)

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation
Autor: Samuel Teo, a další
Vydáno: (2021-06-01)

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease
Autor: Goonho Park, a další
Vydáno: (2020-06-01)

Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
Autor: Carla Álvarez-Ferradas, a další
Vydáno: (2022-10-01)

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
Autor: Sang H. Lee, a další
Vydáno: (2018-08-01)

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.
Autor: Rojo, A, a další
Vydáno: (2017)

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
Autor: Elena M. Ribé, a další
Vydáno: (2005-12-01)

Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures
Autor: Clive Bate, a další
Vydáno: (2018-03-01)

The amyloid precursor protein is a conserved Wnt receptor
Autor: Tengyuan Liu, a další
Vydáno: (2021-09-01)

Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration
Autor: Clive Bate
Vydáno: (2015-01-01)

Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses
Autor: Armando eRomani, a další
Vydáno: (2013-01-01)

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β
Autor: Clive Bate
Vydáno: (2017-10-01)

Commentary: APP as a Mediator of the Synapse Pathology in Alzheimer's Disease
Autor: An Schreurs, a další
Vydáno: (2018-05-01)

Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
Autor: Bor Luen Tang
Vydáno: (2019-06-01)

Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against ABeta oligomers
Autor: Juan Francisco Codocedo, a další
Vydáno: (2015-06-01)

Huntingtin and the Synapse
Autor: Jessica C. Barron, a další
Vydáno: (2021-06-01)

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.
Autor: Marcus O W Grimm, a další
Vydáno: (2012-01-01)

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo
Autor: Raya Al-Shawi, a další
Vydáno: (2016-01-01)

Screening for Familial APP Mutations in Sporadic Cerebral Amyloid Angiopathy
Autor: Biffi, Alessandro, a další
Vydáno: (2011)

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
Autor: Ana I. Rojo, a další
Vydáno: (2017-10-01)

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
Autor: Alejandro Ruiz-Riquelme, a další
Vydáno: (2018-04-01)

Inhibition of AMPA receptor trafficking at hippocampal synapses by β-amyloid oligomers: the mitochondrial contribution
Autor: Rui Yanfang, a další
Vydáno: (2010-03-01)

β-Amyloid precursor protein (APP) and the human diseases
Autor: Khue Vu Nguyen
Vydáno: (2019-10-01)

Clusterin is required for β-Amyloid toxicity in human iPSC-derived neurons
Autor: Robbins, J, a další
Vydáno: (2018)

Masking the transmembrane region of the amyloid β precursor protein as a safe means to lower amyloid β production
Autor: Ayesha Khan, a další
Vydáno: (2023-10-01)

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.
Autor: Isobel J Whitehouse, a další
Vydáno: (2016-01-01)

In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease
Autor: Eugene Kim, a další
Vydáno: (2021-06-01)

Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells
Autor: Emma Ristori, a další
Vydáno: (2020-11-01)

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
Autor: Johannes Steffen, a další
Vydáno: (2017-06-01)

The Drosophila adult neuromuscular junction as a model for unravelling amyloid peptide influence on synapse dynamics
Autor: Begoña Lopez-Arias, a další
Vydáno: (2017-01-01)

α-synuclein induced synapse damage is enhanced by amyloid-β<sub>1-42</sub>
Autor: Williams Alun, a další
Vydáno: (2010-12-01)

Coal Pricing in China: Is It a Bit Too Crude?
Autor: Raymond Li, a další
Vydáno: (2021-06-01)

Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss
Autor: Prameet Kaur, a další
Vydáno: (2022-01-01)

Screening for familial APP mutations in sporadic cerebral amyloid angiopathy.
Autor: Alessandro Biffi, a další
Vydáno: (2010-11-01)

The immunological synapse.
Autor: Bromley, S, a další
Vydáno: (2001)

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Autor: Mohd Waseem Akhtar, a další
Vydáno: (2016-01-01)