A role for APP in Wnt signalling links synapse loss with β-amyloid production

A role for APP in Wnt signalling links synapse loss with β-amyloid production

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synaps...

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Dettagli Bibliografici
Autori principali:	Elliott, C, Rojo, A, Ribe, E, Broadstock, M, Xia, W, Morin, P, Semenov, M, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, C, Simons, P, Killick, R
Natura:	Journal article
Pubblicazione:	Springer Nature 2018

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