A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex
LSD1 and LSD2 are homologous histone demethylases with opposite biological outcomes related to chromatin silencing and transcription elongation, respectively. Unlike LSD1, LSD2 nucleosome-demethylase activity relies on a specific linker peptide from the multidomain protein NPAC. We used single-parti...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Elsevier
2019
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