Actions of aprataxin in multiple DNA repair pathways.
Mutations in the Aptx gene lead to a neurological disorder known as ataxia oculomotor apraxia-1. The product of Aptx is Aprataxin (Aptx), a DNA-binding protein that resolves abortive DNA ligation intermediates. Aprataxin catalyzes the nucleophilic release of adenylate groups covalently linked to 5...
Main Authors: | Rass, U, Ahel, I, West, S |
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Format: | Journal article |
Language: | English |
Published: |
2007
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