How homologous recombination maintains telomere integrity
Telomeres protect the ends of linear chromosomes against loss of genetic information and inappropriate processing as damaged DNA and are therefore crucial to the maintenance of chromosome integrity. In addition to providing a pathway for genome-wide DNA repair, homologous recombination (HR) plays a...
| Main Authors: | , |
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| Format: | Journal article |
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Springer Berlin Heidelberg
2015
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| _version_ | 1826282228960722944 |
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| author | Tacconi, E Tarsounas, M |
| author_facet | Tacconi, E Tarsounas, M |
| author_sort | Tacconi, E |
| collection | OXFORD |
| description | Telomeres protect the ends of linear chromosomes against loss of genetic information and inappropriate processing as damaged DNA and are therefore crucial to the maintenance of chromosome integrity. In addition to providing a pathway for genome-wide DNA repair, homologous recombination (HR) plays a key role in telomere replication and capping. Consistent with this, the genomic instability characteristic of HR-deficient cells and tumours is driven in part by telomere dysfunction. Here, we discuss the mechanisms by which HR modulates the response to intrinsic cellular challenges that arise during telomere replication, as well as its impact on the assembly of telomere protective structures. How normal and tumour cells differ in their ability to maintain telomeres is deeply relevant to the search for treatments that would selectively eliminate cells whose capacity for HR-mediated repair has been compromised. |
| first_indexed | 2024-03-07T00:40:41Z |
| format | Journal article |
| id | oxford-uuid:82ec0ba7-a17d-4be2-bcc6-283d38bab522 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:40:41Z |
| publishDate | 2015 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | oxford-uuid:82ec0ba7-a17d-4be2-bcc6-283d38bab5222022-03-26T21:40:47ZHow homologous recombination maintains telomere integrityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:82ec0ba7-a17d-4be2-bcc6-283d38bab522Symplectic Elements at OxfordSpringer Berlin Heidelberg2015Tacconi, ETarsounas, MTelomeres protect the ends of linear chromosomes against loss of genetic information and inappropriate processing as damaged DNA and are therefore crucial to the maintenance of chromosome integrity. In addition to providing a pathway for genome-wide DNA repair, homologous recombination (HR) plays a key role in telomere replication and capping. Consistent with this, the genomic instability characteristic of HR-deficient cells and tumours is driven in part by telomere dysfunction. Here, we discuss the mechanisms by which HR modulates the response to intrinsic cellular challenges that arise during telomere replication, as well as its impact on the assembly of telomere protective structures. How normal and tumour cells differ in their ability to maintain telomeres is deeply relevant to the search for treatments that would selectively eliminate cells whose capacity for HR-mediated repair has been compromised. |
| spellingShingle | Tacconi, E Tarsounas, M How homologous recombination maintains telomere integrity |
| title | How homologous recombination maintains telomere integrity |
| title_full | How homologous recombination maintains telomere integrity |
| title_fullStr | How homologous recombination maintains telomere integrity |
| title_full_unstemmed | How homologous recombination maintains telomere integrity |
| title_short | How homologous recombination maintains telomere integrity |
| title_sort | how homologous recombination maintains telomere integrity |
| work_keys_str_mv | AT tacconie howhomologousrecombinationmaintainstelomereintegrity AT tarsounasm howhomologousrecombinationmaintainstelomereintegrity |