Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.

The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclero...

詳細記述

書誌詳細
主要な著者: Canning, P, Tan, L, Chu, K, Lee, S, Gray, N, Bullock, A
フォーマット: Journal article
言語:English
出版事項: 2014