Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.

The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclero...

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Detaylı Bibliyografya
Asıl Yazarlar: Canning, P, Tan, L, Chu, K, Lee, S, Gray, N, Bullock, A
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2014