Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the unusual gating properties remain elusive. Here, we...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Chi, G, Liang, Q, Sridhar, A, Cowgill, JB, Sader, K, Radjainia, M, Qian, P, Castro-Hartmann, P, Venkaya, S, Singh, NK, McKinley, G, Fernandez-Cid, A, Mukhopadhyay, SMM, Burgess-Brown, NA, Delemotte, L, Covarrubias, M, Dürr, KL
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Springer Nature 2022

Ижил төстэй зүйлс

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain
-н: Gamma Chi, зэрэг
Хэвлэсэн: (2022-07-01)

CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting
-н: Yangyu Wu, зэрэг
Хэвлэсэн: (2025-02-01)

Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate
-н: Maryam Khoshouei, зэрэг
Хэвлэсэн: (2017-06-01)

Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis
-н: Matzov, Donna, зэрэг
Хэвлэсэн: (2021)

1.8 Å resolution structure of β-galactosidase with a 200 kV CRYO ARM electron microscope
-н: Alan Merk, зэрэг
Хэвлэсэн: (2020-07-01)

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism
-н: Damon JA Frampton, зэрэг
Хэвлэсэн: (2022-06-01)

Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3
-н: Andrei M. Gigolaev, зэрэг
Хэвлэсэн: (2020-07-01)

Effects of intracellular magnesium on Kv1.5 and Kv2.1 potassium channels.
-н: Tammaro, P, зэрэг
Хэвлэсэн: (2005)

Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits
-н: Sara R. Roig, зэрэг
Хэвлэсэн: (2022-06-01)

Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex.
-н: Zhuan Qin, зэрэг
Хэвлэсэн: (2018-11-01)

Volta phase plate cryo-EM of the small protein complex Prx3
-н: Maryam Khoshouei, зэрэг
Хэвлэсэн: (2016-01-01)

Regulation of K<sup>+</sup> Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels
-н: Yuchen Zhang, зэрэг
Хэвлэсэн: (2021-03-01)

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology
-н: Xiao Tao, зэрэг
Хэвлэсэн: (2019-11-01)

Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643
-н: Marlen Dierich, зэрэг
Хэвлэсэн: (2018-01-01)

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
-н: Siew Siew Pang, зэрэг
Хэвлэсэн: (2019-09-01)

Motor starters for voltages above 1 kV a.c. and 1.2 kV d.c.
-н: 8096 British Standards Institution

Analysis of Cell–Cell Bridges in Haloferax volcanii Using Electron Cryo-Tomography Reveal a Continuous Cytoplasm and S-Layer
-н: Shamphavi Sivabalasarma, зэрэг
Хэвлэсэн: (2021-01-01)

Bushings for liquid filled transformers above 1 kV and up to 36 kV
-н: 8096 British Standards Institution

KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat
-н: David Meneses, зэрэг
Хэвлэсэн: (2016-01-01)

The mitochondrial routing of the Kv1.3 channel
-н: Capera, J, зэрэг
Хэвлэсэн: (2022)

The Mitochondrial Routing of the Kv1.3 Channel
-н: Jesusa Capera, зэрэг
Хэвлэсэн: (2022-03-01)

Dynamics of Kv1 channel transport in axons.
-н: Yuanzheng Gu, зэрэг
Хэвлэсэн: (2010-08-01)

Structural characterization of human urea transporters UT-A and UT-B and their inhibition
-н: Chi, G, зэрэг
Хэвлэсэн: (2023)

Modulation of hKv1.1 and hKv1.2 voltage gating and C-type inactivation by 5-HT2C receptors
-н: Imbrici, P, зэрэг
Хэвлэсэн: (2000)

Separable insulated cable connector system above 1 kV and up to 36 kV
-н: 8096 British Standards Institution
Хэвлэсэн: (1990)

Cryo-EM structure of human mitochondrial HSPD1
-н: David P. Klebl, зэрэг
Хэвлэсэн: (2021-01-01)

The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.
-н: Elke Bocksteins, зэрэг
Хэвлэсэн: (2012-01-01)

Structural basis for cytoplasmic dynein-1 regulation by Lis1
-н: John P Gillies, зэрэг
Хэвлэсэн: (2022-01-01)

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
-н: Li, HZ, зэрэг
Хэвлэсэн: (2025)

The KCNE tango – how KCNE1 interacts with Kv7.1
-н: Eva eWrobel, зэрэг
Хэвлэсэн: (2012-08-01)

Cytoplasmic and Nuclear Functions of cIAP1
-н: Aymeric Zadoroznyj, зэрэг
Хэвлэсэн: (2022-02-01)

Interaction of the Zika virus with the cytoplasmic dynein-1
-н: Dan Israel Zavala-Vargas, зэрэг
Хэвлэсэн: (2023-03-01)

Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
-н: Mayumi F. Kohiyama, зэрэг
Хэвлэсэн: (2016-05-01)

Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
-н: Mayumi F. Kohiyama, зэрэг
Хэвлэсэн: (2015-01-01)

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels
-н: Ahmad Elbahnsi, зэрэг
Хэвлэсэн: (2023-06-01)

Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation
-н: Clara M. Poveda, зэрэг
Хэвлэсэн: (2020-01-01)

Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T)
-н: Ina Rothenberg, PhD, зэрэг
Хэвлэсэн: (2016-11-01)

Binding of Hanatoxin to the Voltage Sensor of Kv2.1
-н: Shin-Ho Chung, зэрэг
Хэвлэсэн: (2012-12-01)

Extruded solid dielectric insulated power cables for rated voltages from 1 KV up to 30 KV
-н: 8938 International Electrotechnical Commission

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene
-н: Maria Cristina D'Adamo, зэрэг
Хэвлэсэн: (2015-01-01)