Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the unusual gating properties remain elusive. Here, we...

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Bibliographische Detailangaben
Hauptverfasser:	Chi, G, Liang, Q, Sridhar, A, Cowgill, JB, Sader, K, Radjainia, M, Qian, P, Castro-Hartmann, P, Venkaya, S, Singh, NK, McKinley, G, Fernandez-Cid, A, Mukhopadhyay, SMM, Burgess-Brown, NA, Delemotte, L, Covarrubias, M, Dürr, KL
Format:	Journal article
Sprache:	English
Veröffentlicht:	Springer Nature 2022

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