Structural basis for GABAA receptor potentiation by neurosteroids

Structural basis for GABAA receptor potentiation by neurosteroids

Type A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of inhibitory neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to regulate acute and chronic anxiety and are potent sedative, analgesic, anticonvulsant and anesthetic agents. Their mode of...

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Bibliographic Details
Main Authors:	Miller, P, Scott, S, Masiulis, S, De Colibus, L, Pardon, E, Steyaert, J, Aricescu, A
Format:	Journal article
Language:	English
Published:	Springer Nature 2017

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