Structural basis for GABAA receptor potentiation by neurosteroids

Structural basis for GABAA receptor potentiation by neurosteroids

Type A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of inhibitory neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to regulate acute and chronic anxiety and are potent sedative, analgesic, anticonvulsant and anesthetic agents. Their mode of...

书目详细资料
Main Authors:	Miller, P, Scott, S, Masiulis, S, De Colibus, L, Pardon, E, Steyaert, J, Aricescu, A
格式:	Journal article
语言:	English
出版:	Springer Nature 2017

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