Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.
The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2...
Үндсэн зохиолчид: | Goodall, J, Carreira, S, Denat, L, Kobi, D, Davidson, I, Nuciforo, P, Sturm, R, Larue, L, Goding, C |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2008
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