Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.

Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.

The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2...

书目详细资料
Main Authors:	Goodall, J, Carreira, S, Denat, L, Kobi, D, Davidson, I, Nuciforo, P, Sturm, R, Larue, L, Goding, C
格式:	Journal article
语言:	English
出版:	2008

相似书籍

The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes.
由: Carreira, S, et al.
出版: (2000)

The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression.
由: Schepsky, A, et al.
出版: (2006)

CBP/p300 as a co-factor for the Microphthalmia transcription factor.
由: Sato, S, et al.
出版: (1997)

The Brn-2 transcription factor links activated BRAF to melanoma proliferation.
由: Goodall, J, et al.
出版: (2004)

The role of the transcription factor BRN2 in melanoma
由: Herbert, K
出版: (2018)

Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo.
由: Aksan, I, et al.
出版: (1998)

Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.
由: Goodall, J, et al.
出版: (2004)

The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription.
由: Yavuzer, U, et al.
出版: (1995)

Direct regulation of the Microphthalmia promoter by Sox10 links Waardenburg-Shah syndrome (WS4)-associated hypopigmentation and deafness to WS2.
由: Lee, M, et al.
出版: (2000)

The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
由: Eisen, T, et al.
出版: (1995)

Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.
由: Carreira, S, et al.
出版: (2006)

Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.
由: Goding, C, et al.
出版: (2006)

Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator.
由: Bentley, N, et al.
出版: (1994)

A two base pair deletion in the PQBP1 gene is associated with microphthalmia, microcephaly, and mental retardation.
由: Martínez-Garay, I, et al.
出版: (2007)

Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.
由: Carreira, S, et al.
出版: (1998)

Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR.
由: Ng, D, et al.
出版: (2004)

Transcription regulation in melanocytes and melanoma
由: Goding, C
出版: (2008)

Repressive Transcription
由: Young, Richard A., et al.
出版: (2013)

Trends over time in the incidence of congenital anophthalmia, microphthalmia and orbital malformation in England: database study
由: Dharmasena, A, et al.
出版: (2016)

Regulation of MITF and Brn2 in melanoma
由: Agkatsev, S
出版: (2014)

The two activation domains of the Brn-3a transcription factor have distinct functional properties
由: Begbie, J, et al.
出版: (1997)

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
由: Herbert, K, et al.
出版: (2019)

BRN2 is a non-canonical melanoma tumor-suppressor
由: Hamm, M, et al.
出版: (2021)

Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations
由: Bury, Leah, et al.
出版: (2021)

Importance of BRN2 phosphorylation for melanocyte migration
由: Berlin, I, et al.
出版: (2011)

The transcription network regulating melanocyte development and melanoma.
由: Vance, K, et al.
出版: (2004)

GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription.
由: Nerlov, C, et al.
出版: (2000)

A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma.
由: Bonvin, E, et al.
出版: (2012)

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
由: Jessen, C, et al.
出版: (2020)

Transcriptional control of phenotype in melanoma
由: Mosteo López, L
出版: (2019)

T-box transcription factors in cancer biology.
由: Wansleben, S, et al.
出版: (2014)

Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.
由: Goding, C
出版: (2000)

The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.
由: Galibert, MD, et al.
出版: (2001)

NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF
由: Fane, M, et al.
出版: (2017)

Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors
由: Yu, Ming, et al.
出版: (2014)

T-box factors in melanocytes and melanoma
由: Goding, C
出版: (2008)

CRISPR-Mediated Transcriptional Repression in Toxoplasma gondii
由: Markus, Benedikt M, et al.
出版: (2022)

BRN2 phosphorylation regulates melanoblast migration and proliferation through PAX3 and MITF-M
由: Berlin, I, et al.
出版: (2011)

Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion
由: Fane, M, et al.
出版: (2021)

Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.
由: Berlin, I, et al.
出版: (2012)