Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.

Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.

The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2...

书目详细资料
Main Authors:	Goodall, J, Carreira, S, Denat, L, Kobi, D, Davidson, I, Nuciforo, P, Sturm, R, Larue, L, Goding, C
格式:	Journal article
语言:	English
出版:	2008

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