KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis.

KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis.

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The human leukocyte Ag HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 can be expressed at the cell surface of APC as both classical β2-microglobulin-associated B27 and B27 free H chain forms (FHC), including disulfide-bonded H chain homodimers (termed B27(2)). B27 FHC forms,...

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Autores principales: Wong-Baeza, I, Ridley, A, Shaw, J, Hatano, H, Rysnik, O, McHugh, K, Piper, C, Brackenbridge, S, Fernandes, R, Chan, A, Bowness, P, Kollnberger, S
Formato: Journal article
Lenguaje:English
Publicado: 2013

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