Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner.

Embryonic stem cells and embryonal carcinoma P19 cells produce erythropoietin (Epo) in an oxygen-independent manner, although lactate dehydrogenase A (LDHA) is hypoxia-inducible. To explore this paradox, we studied the operation of cis-acting sequences from these genes in P19 and Hep3B cells. The Ep...

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Bibliographic Details
Main Authors: Kambe, T, Tada, J, Chikuma, M, Masuda, S, Nagao, M, Tsuchiya, T, Ratcliffe, P, Sasaki, R
Format: Journal article
Language:English
Published: 1998